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产品规格
可售数量： 500ug
产品参数
| Ex (nm) | - | Em (nm) | - |
| 分子量 | N/A | 溶剂 | DMSO |
| 存储条件 | 在零下15度以下保存, 避免光照 |
产品概述
产品基本信息
产品名称：2'，3'-cGAMP叠氮化物
储存条件：-15℃避光防潮
保质期：12个月
产品物理化学光谱特性
分子量：1144.14
外观：固体
溶剂：DMSO
激发波长(nm)：NA
发射波长(nm)：NA
产品介绍
2'，3'-cGAMP叠氮化物是将2'，3'-cGAMP偶联到炔烃修饰的生物靶标（如蛋白质、肽和核酸）的优良试剂。近年来，2'，3'-cGAMP因其作为癌症和病毒感染等的潜在靶点而备受关注。研究表明，免疫检查点抑制剂是一种癌症免疫疗法。2'，3'-cGAMP（环状GMP-AMP）是一种环状二核苷酸di二信使分子，在先天免疫系统中发挥关键作用。它是由cGAS（环状GMP-AMP合酶）对受损或感染细胞释放的胞质DNA作出反应而合成的。一旦合成，2'，3'-cGAMP与衔接蛋白STING（干扰素基因的刺激因子）结合，并触发下游信号通路，从而产生I型干扰素和其他细胞因子，从而产生对抗入侵病原体的免疫反应。
溶解方案(溶剂以说明书为准)
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 87.402 µL | 437.009 µL | 874.019 µL | 4.37 mL | 8.74 mL |
| 5 mM | 17.48 µL | 87.402 µL | 174.804 µL | 874.019 µL | 1.748 mL |
| 10 mM | 8.74 µL | 43.701 µL | 87.402 µL | 437.009 µL | 874.019 µL |
参考文献
Spermidine enhances the efficacy of adjuvant in HBV vaccination in mice.
Authors: Ito, Daisuke and Ito, Hiroyasu and Ando, Tatsuya and Sakai, Yasuhiro and Ideta, Takayasu and Ishii, Ken J and Ishikawa, Tetsuya and Shimizu, Masahito
Journal: Hepatology communications (2023)
Microcystin-LR-induced nuclear translocation of cGAS promotes mutagenesis in human hepatocytes by impeding homologous recombination repair.
Authors: Wang, Xiaofei and Zhu, Yuchen and Lu, Wenzun and Guo, Xiaoying and Chen, Liuzeng and Zhang, Ning and Chen, Shaopeng and Ge, Chunmei and Xu, Shengmin
Journal: Toxicology letters (2023): 94-104
Responsive manganese-based nanoplatform amplifying cGAS-STING activation for immunotherapy.
Authors: He, Qingbin and Zheng, Runxiao and Ma, Junchi and Zhao, Luyang and Shi, Yafang and Qiu, Jianfeng
Journal: Biomaterials research (2023): 29
TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.
Authors: Wang, Jie and Qin, Xiao and Huang, Yulu and Zhang, Qunmei and Pei, Jinyong and Wang, Yi and Goren, Idan and Ma, Shujun and Song, Zhishan and Liu, Yanzi and Xing, Hongxia and Wang, Hui and Yang, Bo
Journal: Autophagy (2023): 1-19
Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides cth GAMP.
Authors: Veth, Simon and Fuchs, Adrian and Özdemir, Dilara and Dialer, Clemens and Drexler, David Jan and Knechtel, Fabian and Witte, Gregor and Hopfner, Karl-Peter and Carell, Thomas and Ploetz, Evelyn
Journal: Chembiochem : a European journal of chemical biology (2022): e202200005
Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy.
Authors: Zhang, Zili and Zhou, Haifeng and Ouyang, Xiaohu and Dong, Yalan and Sarapultsev, Alexey and Luo, Shanshan and Hu, Desheng
Journal: Signal transduction and targeted therapy (2022): 394
Cell-Free DNA Promotes Inflammation in Patients With Oral Lichen Planus via the STING Pathway.
Authors: Deng, Jing and Pan, Weiyi and Ji, Ning and Liu, Na and Chen, Qian and Chen, Jinhuan and Sun, Yutong and Xie, Liang and Chen, Qianming
Journal: Frontiers in immunology (2022): 838109
Development of a High-Throughput Assay to Identify Inhibitors of ENPP1.
Authors: Kumar, Meera and Lowery, Robert G
Journal: SLAS discovery : advancing life sciences R & D (2021): 740-746
Synthesis and biological evaluation of all possible inosine-mixed cyclic dinucleotides that activate different hSTING variants.
Authors: Wang, Zhenghua and Zhao, Cancan and Wang, Chuanlin and Zhang, Hang and Ma, Dejun and Zhang, Qiangzhe and Wen, Xin and Li, Luyuan and Xi, Zhen
Journal: Bioorganic & medicinal chemistry (2021): 115899
HFE inhibits type I IFNs signaling by targeting the SQSTM1-mediated MAVS autophagic degradation.
Authors: Liu, Juan and Wu, Xiaopeng and Wang, Hailong and Wei, Jiayu and Wu, Qian and Wang, Xingbo and Yan, Yan and Cui, Jun and Min, Junxia and Wang, Fudi and Zhou, Jiyong
Journal: Autophagy (2021): 1962-1977
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18502920169
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029-68064558
AAT Bioquest 2'，3'-cGAMP叠氮化物 货号20332
¥面议
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